Bridging Science and Practice: Leading Translational Research in Cardio-immunology and Pediatric Cardiac Medicine
As a dedicated researcher in cardioimmunology and pediatric cardiac medicine, I am renowned for my commitment to translational research, striving to bridge the gap between scientific discoveries and clinical applications. My journey extends beyond traditional academic boundaries, focusing on translating findings into practical advancements in patient care. Furthermore, my extensive array of certifications, including PPCR, Clinical Investigator, Foundations in R, Felasa B, Foundation in Immunology, and Career Program for Female Researchers, reflects my dedication to advancing medical knowledge and fostering innovative approaches in healthcare delivery. These certifications equip me with the necessary skills and expertise to navigate the intricate intersections of research and clinical practice, ultimately enhancing outcomes for patients and advancing the field of cardiovascular medicine.
Grants and Funds
August 2022
Funding of the City of Graz, Austria - Project: Targeted inhibition of the innate immune pathway cGAS-STING to improve ischemic cardiac remodelling in females
December 2021
USA Scholarships of the MAX KADE Foundation - Austrian Academy of Sciences
November 2021
The Marshall Plan Scholarships - Austrian Marshall Plan Foundation
June 2019
ESC Grant for the Basic Science Summer School - Nice, France
Speech on the award of the Max Kade Fellowship by the Austrian Academy of Sciences (speech in German)
Publications
Diaz-Gil D., Gierlinger G., Silva-Gomez N., Rech L., Ortiz-Urbina J., Saraci K., Koutsogiannaki S., Wolf C., Kozlik-Feldmann R., Mair R., Melero-Martin J., Emani S., Garcia-Cardena G., del Nido P., Friehs I.
Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis
Submitted (Preprint JACC BTS doi: 10.2139/ssrn.4690651)
La Gouge K., Ashour D., Heinrichs, M., Stys P., Barennes P., Stangl V., Rech L., Höfler G., Kashofer K., Gassenmaier T., Boivin-Jahns V., Jahns R., Hofmann U., Schmitt D., Frey A., Störk S., Frantz S., Rainer P., Ramos G., Mariotti-Ferrandiz E.
A distinct cell receptor signature associates with cardiac outcome in myocardial infarction patients
Submitted (Preprint medRxiv doi: 10.1101/2023.11.23.23298725)
Vivanco R.*, Rech L.*, Ramos-Orosco E., Prilip P., Mengide J., Rivera P., Vergas-Riuz A., Barros L., Abbarth S., Aspee R., Bazan-Perkins B., Ninapaytan G., Felipe M., Guersoni A., Guiterrez-Brito G., Hoessly L., Hussein N., Lobo, M., Nakamura G., Mohamed W., Roedinger M., Salman D., Teo T., Siqueira A.
Transcranial Magnetic Stimulation of Dorsolateral Prefrontal Cortex in Treatment-Resistant Obsessive Compulsive Disorder: A Mini-Review
(*Co-First Authors)
Accepted – Principles and Practise of Clinical Research
G. Gierlinger, L.Rech, S. Emani, P. del Nido, I. Friehs
A neonatal heterotopic rat heart transplantation model for the study of endothelial-to-mesenchymal transition
J. Vis. Exp. (197), e65426
N. Mabotuwana, D. Skerrett-Byrne, D. Ashour, L. Butel-Simões, M. McGee, L. Rech, S. Hardy, R. Mejia, R. Lee, S. Lim, J. Hare, G. Ramos, L. Murtha, M. Dun, P. Rainer, A. Boyle
Quantitative proteomic profiling of human mesenchymal stem cells derived from bone marrow and cardiac tissue identifies unique paracrine factors that may promote cardiac repair
In Revision
N. Mabotuwana, L. Rech, J. Lim, S. Hardy, L.A. Murtha, P.P. Rainer, A.J. Boyle
Paracrine factors released by mesenchymal stem cells and their effects in cardiovascular disease: A systematic review of pre-clinical studies
Stem Cell Rev and Rep 2022, s12015-022-10429-6
S. Hardy, R. Patrick, L. Liesinger, M. Pöttler, L. Rech, J. Grindlhuber, N. Mabotuwana, V. Stangl, M. Bigland, L.A. Murtha, M. Starkey, D. Scheer, P.M. Hansbro, G.Höfler, R. Harvey, R. Birner-Grünberger, A.J. Boyle, P.P. Rainer
Extracellular matrix protein 1 as a critical mediator of inflammation-induced fibrosis after myocardial infarction
Am Coll Cardiol Basic Trans Science. 2023 Aug 16;8(12):1539-1554
L. Rech, M. Abdellatif, M. Pöttler, V. Stangl, N. Mabotuwana, S. Hardy, P.P. Rainer
Small molecule STING inhibition improves myocardial infarction remodeling
Life Sciences 2022 (291) 120263
L. Rech, P.P. Rainer
Grundlagen- und translationale Forschung beim ESC 2021
Universum Innere Medizin 2021 (Supp. 08) 48-49
L. Rech, P.P. Rainer
The innate immune cGAS-STING-pathway in cardiovascular disease – A mini review
Front. Cardiovasc. Med. 2021 July 26; 715903
L. Spray, C. Park, S. Cormack, A. Mohammed, P. Oanahi, S. Boag, K. Bennaceur, K. Sopova, G. Richardson, V. Stangl, L. Rech, P.P. Rainer, G.C. Ramos, U. Hofmann, K. Stellos, I. Spyridopoulos
The fractalkine receptor CX3CR1 links lymphocyte kinetics in CMV-seropositive patients and acute myocardial infarction with adverse left ventricular remodeling
Front Immunol 2021 May 05; 12:605857
L. Rech, P.P. Rainer
Potenzial antiinflammatorischer Therapien bei kardiovaskulären Erkrankungen
Universum Innere Medizin 2021 (Suppl 02) 12-13
M. Abdellatif, V. Trummer-Herbst, F. Koser, S. Durand, R. Adão, F. Vasques-Nóvoa, J.K. Freundt, J. Voglhuber, M-R. Pricolo, M.Kasa, C. Türk, F. Aprahamian, E. Herrero-Galán, S.J. Hofer, T. Pendl, L. Rech, J. Kargl, N. Anto-Michel, S. Ljubojevic-Holzer, J. Schipke, C. Brandenberger, M. Auer, R. Schreiber, C.N. Koyani, A. Heinemann, A. Zirlik, A. Schmidt, D. von Lewinski, D. Scherr, P.P. Rainer, J. von Maltzahn, C. Mühlfeld, M. Krüger, S. Frank, F. Madeo, T. Eisenberg, A. Prokesch , A.F. Leite-Moreira, A.P. Lourenço, J. Alegre-Cebollada, S. Kiechl, W.A. Linke, G. Kroemer , S. Sedej
Nicotinamide for treatment of heart failure with preserved ejection fraction
Sci. Transl. Med. 2021 13 (580) eabd7064
J. Prasch, E. Bernhart, H. Reicher, M. Kollroser, G.N. Rechberger, C.N. Koyani, C. Trummer, L. Rech, P.P. Rainer, A. Hammer, E. Malle, W. Sattler
Myeloperoxidase-Derived 2-Chlorohexadecanal is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro
Int. J. Mol. Sci. 2020, 21, 9235.
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